Acid mucopolysaccharides of chick-embryo cartilage in osteolathyrism

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Acid mucopolysaccharides of chick-embryo cartilage in osteolathyrism.

1. In view of the suggested association between collagen and acid mucopolysaccharides in the connective tissues, this study was designed to see whether the lathyrus factor, beta-aminopropionitrile, affected the acid mucopolysaccharides as well as inhibiting the normal polymerization of collagen. The changing pattern of these two components of cartilage from normal and lathyritic chick embryos a...

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Chick-Embryo Cartilage in vivo

1. Treatment ofthe chick embryo with the lathyrus factor, ,-aminopropionitrile, produces inhibition of polymerization of newly synthesized collagen at the interand intra-molecular level (Levene & Gross, 1959; Martin, Gross, Piez & Lewis, 1961); this is manifest as an increase in the fragility and solubility of collagen from the connective tissues. 2. This treatment simultaneously produced incre...

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ژورنال

عنوان ژورنال: Biochemical Journal

سال: 1966

ISSN: 0006-2936

DOI: 10.1042/bj1010435